XRCC3基因Thr241Met多態性與中國人肺癌易感性關系的Meta分析_《中國循證醫學雜志》

作者：

鄭巧玲 , 張含瓊 , 張承 ,  徐剛

四川省成都市雙流縣第一人民醫院內四科（成都 610200）;

關鍵詞：

XRCC3 基因多態性中國人肺癌 Meta分析

DOI：

10.7507/1672-2531.20130185

視頻：

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目的　系統評價XRCC3基因Thr241Met多態性與中國人肺癌發病風險的相關性。
方法　計算機檢索PubMed、EMbase、CNKI、VIP和WanFang Data，查找國內外關于XRCC3基因Thr241Met多態性與中國人群肺癌易感性關系的研究，檢索時限均為建庫至2013年8月20日。由2名評價者根據納入與排除標準獨立篩選文獻，提取資料并評價質量后，采用RevMan 5.0軟件和Stata 10.0軟件進行Meta分析，采用Egger’s線性回歸法分析發表偏倚。
結果　最終納入5個研究，包括肺癌患者2 999例，對照2 994例。Meta分析結果顯示：對于中國人群而言，攜帶XRCC3基因Thr241Met多態性突變基因型/等位基因的個體肺癌發病風險不會明顯增加：Met/Met vs. Thr/Thr：OR=1.00，95%CI（0.38，2.59），P=0.99；Met/Met vs. Thr/Met：OR=1.06，95%CI（0.83，1.36），P=0.63；Met/Met vs. Thr/Met+Thr/Thr：OR=0.99，95%CI（0.38，2.57），P=0.98；Thr/Met+Met/Met vs. Thr/Thr：OR=1.06，95%CI（0.82，1.37），P=0.65；Met vs. Thr：OR=1.05，95%CI（0.82，1.35），P=0.68。
結論　目前尚未發現XRCC3基因Thr241Met多態性與中國人群肺癌發病風險相關。受納入研究數量的限制，上述結論需更多高質量大樣本研究進一步驗證。

引用本文： 鄭巧玲,張含瓊,張承,徐剛. XRCC3基因Thr241Met多態性與中國人肺癌易感性關系的Meta分析. 中國循證醫學雜志, 2013, 13(9): 1080-1083. doi: 10.7507/1672-2531.20130185 復制

1.	Chen Z, Xu L, Ye X, et al. Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review. PloS One, 2013, 8(4): e61008.
2.	Jacobsen NR, Raaschou-Nielsen O, Nexo B, et al. XRCC3 polymorphisms and risk of lung cancer. Cancer lett, 2004, 213(1): 67-72.
3.	Jeon HS, Jin G, Kang HG, et al. A Functional Variant at 19q13.3, rs967591G>A, Is Associated with Shorter Survival of Early-Stage Lung Cancer. Clin Cancer Res, 2013, 19(15): 4185-4195.
4.	Liu ZB, Shu J, Wang LP, et al. Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis. Mol Bio Rep, 2013, 40(9): 5255-5259.
5.	Manuguerra M, Saletta F, Karagas MR, et al. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Am J Epidemiol, 2006, 164(4): 297-302.
6.	Qian B, Zhang H, Zhang L, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
7.	Ryk C, Kumar R, Thirumaran RK, et al. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. Lung Cancer, 2006, 54(3): 285-292.
8.	Sun H, Qiao Y, Zhang X, et al. XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: a meta-analysis. Cancer Sci, 2010, 101(8): 1777-1782.
9.	Wang Y, Liang D, Spitz MR, et al. XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. Cancer, 2003, 98(8): 1701-1706.
10.	Guo SJ, Li XB, Gao M, et al. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PloS One, 2013, 8(2): e56213.
11.	Qian BY, Zhang H, Zhang LN, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
12.	夏文進, 張毅敏, 蘇丹, 等. 人類XRCC3-241單核苷酸多態性與非小細胞性肺癌的易感性研究. 浙江醫學, 2008, 30(12): 1291-1293.
13.	陳曉雯, 李玲, 楊聲杰. PC-1基因外顯子4多態性與中國人2型糖尿病相關性的系統評價. 中國循證醫學雜志, 2013, 13(3): 308-312.
14.	張本龍, 施小柯. 雌激素受體α基因多態性與中國女性子宮內膜異位癥相關性的系統評價. 中國循證醫學雜志, 2013, 13(3): 320-324.
15.	Zhang YG, Li XB, Zhang J, et al. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy, 2011, 66(2): 197-205.
16.	冉恒泉, 周勇, 陳博, 等. MDM2-309 T>G 基因多態性與東亞人群胃癌風險關系的Meta分析. 中國循證醫學雜志, 2013, 13(5): 560-3.
17.	黃萌. XRCC3基因多態性、環境與肺癌的關聯. 學位論文: 福建醫科大學, 2010.
18.	梁剛. DNA修復基因和致癌物代謝基因單核苷酸多態與肺癌遺傳易感性. 學位論文: 中國協和醫科大學, 2004.
19.	Yin J, Vogel U, Ma Y, et al. HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population. Carcinogenesis, 2009, 30(7): 1181-1185.
20.	Liu D, Wang F, Guo X, et al. Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population. Mol Bio Rep, 2013, 40(1): 645-649.
21.	Chen J, Zhao QW, Shi GM, et al. XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. Journal of Zhejiang University Science B, 2012, 13(11): 875-883.

1. Chen Z, Xu L, Ye X, et al. Polymorphisms of microRNA sequences or binding sites and lung cancer: a meta-analysis and systematic review. PloS One, 2013, 8(4): e61008.
2. Jacobsen NR, Raaschou-Nielsen O, Nexo B, et al. XRCC3 polymorphisms and risk of lung cancer. Cancer lett, 2004, 213(1): 67-72.
3. Jeon HS, Jin G, Kang HG, et al. A Functional Variant at 19q13.3, rs967591G>A, Is Associated with Shorter Survival of Early-Stage Lung Cancer. Clin Cancer Res, 2013, 19(15): 4185-4195.
4. Liu ZB, Shu J, Wang LP, et al. Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: a meta-analysis. Mol Bio Rep, 2013, 40(9): 5255-5259.
5. Manuguerra M, Saletta F, Karagas MR, et al. XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE review. Am J Epidemiol, 2006, 164(4): 297-302.
6. Qian B, Zhang H, Zhang L, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
7. Ryk C, Kumar R, Thirumaran RK, et al. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. Lung Cancer, 2006, 54(3): 285-292.
8. Sun H, Qiao Y, Zhang X, et al. XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: a meta-analysis. Cancer Sci, 2010, 101(8): 1777-1782.
9. Wang Y, Liang D, Spitz MR, et al. XRCC3 genetic polymorphism, smoking, and lung carcinoma risk in minority populations. Cancer, 2003, 98(8): 1701-1706.
10. Guo SJ, Li XB, Gao M, et al. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PloS One, 2013, 8(2): e56213.
11. Qian BY, Zhang H, Zhang LN, et al. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer, 2011, 73(2): 138-146.
12. 夏文進, 張毅敏, 蘇丹, 等. 人類XRCC3-241單核苷酸多態性與非小細胞性肺癌的易感性研究. 浙江醫學, 2008, 30(12): 1291-1293.
13. 陳曉雯, 李玲, 楊聲杰. PC-1基因外顯子4多態性與中國人2型糖尿病相關性的系統評價. 中國循證醫學雜志, 2013, 13(3): 308-312.
14. 張本龍, 施小柯. 雌激素受體α基因多態性與中國女性子宮內膜異位癥相關性的系統評價. 中國循證醫學雜志, 2013, 13(3): 320-324.
15. Zhang YG, Li XB, Zhang J, et al. The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis. Allergy, 2011, 66(2): 197-205.
16. 冉恒泉, 周勇, 陳博, 等. MDM2-309 T>G 基因多態性與東亞人群胃癌風險關系的Meta分析. 中國循證醫學雜志, 2013, 13(5): 560-3.
17. 黃萌. XRCC3基因多態性、環境與肺癌的關聯. 學位論文: 福建醫科大學, 2010.
18. 梁剛. DNA修復基因和致癌物代謝基因單核苷酸多態與肺癌遺傳易感性. 學位論文: 中國協和醫科大學, 2004.
19. Yin J, Vogel U, Ma Y, et al. HapMap-based study of the DNA repair gene ERCC2 and lung cancer susceptibility in a Chinese population. Carcinogenesis, 2009, 30(7): 1181-1185.
20. Liu D, Wang F, Guo X, et al. Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population. Mol Bio Rep, 2013, 40(1): 645-649.
21. Chen J, Zhao QW, Shi GM, et al. XRCC1 Arg399Gln and clinical outcome of platinum-based treatment for advanced non-small cell lung cancer: a meta-analysis in 17 studies. Journal of Zhejiang University Science B, 2012, 13(11): 875-883.

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XRCC3基因Thr241Met多態性與中國人肺癌易感性關系的Meta分析

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《中國循證醫學雜志》

XRCC3基因Thr241Met多態性與中國人肺癌易感性關系的Meta分析

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