表皮細胞因子61基因多態性與食管癌易感性的Meta分析_《中國循證醫學雜志》

作者：

王軍 ,  董衛國 , 郭緒峰 , 余世界 , 宋佳 , 張吉翔 , 王靜

武漢大學人民醫院消化內科（武漢 430060）;

關鍵詞：

EGF 食管癌基因多態性系統評價 Meta分析病例-對照研究

DOI：

10.7507/1672-2531.20130207

視頻：

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目的　系統評價表皮細胞因子（epidermal growth factor, EGF）基因61A/G多態性與食管癌風險的相關性。
方法　計算機檢索PubMed、EMbase、CJFD、CBM、CNKI、VIP及WanFang Data，檢索時限從建庫至2013年1月1日，收集關于EGF基因61A/G多態性與食管癌發病風險的病例-對照研究。由2位評價者按照納入和排除標準獨立選擇文獻、提取資料和評價質量后，采用RevMan 5.1和Stata 12.0軟件進行Meta分析。
結果　共納入6個病例-對照研究，1 448例食管癌患者和1 728例健康對照人群。Meta分析結果顯示，EGF基因61A/G多態性與食管癌風險的相關性無統計學意義：顯性遺傳模型［AG+GG vs. AA：OR=1.22，95%CI（0.91，1.65）］；隱性遺傳模型［GG vs. AG+AA：OR=1.35，95%CI（0.94，1.94）；AG vs. AA：OR=1.12，95%CI（0.93，1.35）；GG vs. AA：OR=1.43，95%CI（0.83，2.47）］。基于人種的亞組分析顯示，EGF基因61A/G多態性可增加白種人罹患食管癌的風險：顯性遺傳模型［AG+GG vs. AA：OR=1.39，95%CI（1.14，1.71）］；隱性遺傳模型［GG vs. AG+AA：OR=1.75，95%CI（1.37，2.25）；GG vs. AA：OR=1.93，95%CI（1.47，2.55）］。但與亞洲人群食管癌風險無明顯相關。
結論　基于目前研究結果，可以認為EGF基因61A/G多態性與食管癌易感性無明顯相關性，而EGF基因61A/G多態性可能增加白種人罹患食管癌風險。受納入研究的數量和質量限制，以上結論需要大樣本研究進行驗證。

引用本文： 王軍,董衛國,郭緒峰,余世界,宋佳,張吉翔,王靜. 表皮細胞因子61基因多態性與食管癌易感性的Meta分析. 中國循證醫學雜志, 2013, 13(10): 1209-1214. doi: 10.7507/1672-2531.20130207 復制

1.	Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
2.	Boonyaphiphat P, Thongsuksai P, Sriplung H, et al. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett, 2002, 186(2): 193-199.
3.	Li TF, Ren KW, Liu PF. Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls. DNA Cell Biol, 2012, 31(4): 568-574.
4.	Kasza A. IL-1 and EGF regulate expression of genes important in inflammation and cancer. Cytokine, 2013, 62(1): 22-33.
5.	Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med, 1997, 127(9): 820-826.
6.	Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719-748.
7.	DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3): 177-188.
8.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
9.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
10.	Cheung WY, Zhai R, Kulke MH, et al. Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk. Carcinogenesis, 2009, 30(8): 1363-1367.
11.	Cui L, Pan XM, Ma CF, et al. Association between epidermal growth factor polymorphism and esophageal squamous cell carcinoma susceptibility. Dig Dis Sci, 2010, 55(1): 40-45.
12.	Lanuti M, Liu G, Goodwin JM, et al. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res, 2008, 14(10): 3216-3222.
13.	Menke V, Pot RG, Moons LM, et al. Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett’s esophagus and esophageal adenocarcinoma. J Hum Genet, 2012, 57(1): 26-32.
14.	Upadhyay R, Jain M, Kumar S, et al. Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. Oncol Res, 2008, 17(4): 167-174.
15.	夏晴暉, 壽明霞, 陳岳明. 表皮生長因子G61A多態性與食管鱗狀細胞癌發生及其病理特征之間的關系. 中華實驗外科雜志, 2011, 28(12): 2229.
16.	Lurje G, Leers JM, Pohl A, et al. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg, 2010, 251(5): 857-864.
17.	Jain M, Kumar S, Upadhyay R, et al. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther, 2007, 6(10): 1553-1558.
18.	唐巍峰, 孫斌, 顧海勇, 等. COX-2基因多態性與食管癌易感性關系的Meta分析. 中國循證醫學雜志, 2011, 11(12): 1391-1394.
19.	Piao Y, Liu Z, Ding Z, et al. EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis. Gene, 2013, 519(1): 26-33.
20.	Zhang G, Zhang Q, Zhang Q, et al. Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. J Cancer Res Clin Oncol, 2010, 136(4): 587-594.
21.	Boccia S, De Feo E, Galli P, et al. A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research. Eur J Epidemiol, 2010, 25(11): 765-775.

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011, 61(2): 69-90.
2. Boonyaphiphat P, Thongsuksai P, Sriplung H, et al. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett, 2002, 186(2): 193-199.
3. Li TF, Ren KW, Liu PF. Meta-analysis of epidermal growth factor polymorphisms and cancer risk: involving 9,779 cases and 15,932 controls. DNA Cell Biol, 2012, 31(4): 568-574.
4. Kasza A. IL-1 and EGF regulate expression of genes important in inflammation and cancer. Cytokine, 2013, 62(1): 22-33.
5. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med, 1997, 127(9): 820-826.
6. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 1959, 22(4): 719-748.
7. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials, 1986, 7(3): 177-188.
8. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
9. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
10. Cheung WY, Zhai R, Kulke MH, et al. Epidermal growth factor A61G gene polymorphism, gastroesophageal reflux disease and esophageal adenocarcinoma risk. Carcinogenesis, 2009, 30(8): 1363-1367.
11. Cui L, Pan XM, Ma CF, et al. Association between epidermal growth factor polymorphism and esophageal squamous cell carcinoma susceptibility. Dig Dis Sci, 2010, 55(1): 40-45.
12. Lanuti M, Liu G, Goodwin JM, et al. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res, 2008, 14(10): 3216-3222.
13. Menke V, Pot RG, Moons LM, et al. Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett’s esophagus and esophageal adenocarcinoma. J Hum Genet, 2012, 57(1): 26-32.
14. Upadhyay R, Jain M, Kumar S, et al. Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. Oncol Res, 2008, 17(4): 167-174.
15. 夏晴暉, 壽明霞, 陳岳明. 表皮生長因子G61A多態性與食管鱗狀細胞癌發生及其病理特征之間的關系. 中華實驗外科雜志, 2011, 28(12): 2229.
16. Lurje G, Leers JM, Pohl A, et al. Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg, 2010, 251(5): 857-864.
17. Jain M, Kumar S, Upadhyay R, et al. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther, 2007, 6(10): 1553-1558.
18. 唐巍峰, 孫斌, 顧海勇, 等. COX-2基因多態性與食管癌易感性關系的Meta分析. 中國循證醫學雜志, 2011, 11(12): 1391-1394.
19. Piao Y, Liu Z, Ding Z, et al. EGF +61A>G polymorphism and gastrointestinal cancer risk: a HuGE review and meta-analysis. Gene, 2013, 519(1): 26-33.
20. Zhang G, Zhang Q, Zhang Q, et al. Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues. J Cancer Res Clin Oncol, 2010, 136(4): 587-594.
21. Boccia S, De Feo E, Galli P, et al. A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research. Eur J Epidemiol, 2010, 25(11): 765-775.

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表皮細胞因子61基因多態性與食管癌易感性的Meta分析

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《中國循證醫學雜志》

表皮細胞因子61基因多態性與食管癌易感性的Meta分析

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